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The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disord...
This book details the outcomes of new research focusing on climate risk related to hurricanes. Topics include numerical simulation of tropical cyclones, through tropical cyclone hazard estimation to damage estimates and their implications for commercial risk. Inspired by the 6th International Summit on Hurricanes and Climate Change: From Hazard to Impact, this book brings together leading international academics and researchers, and provides a source reference for both risk managers and climate scientists for research on the interface between tropical cyclones, climate and risk.
** Shortlisted for the Military History Matters Book of the Year Award ** 'Magnificent. Narrative history at its vivid and compelling best' Fergal Keane The first major history of the International Brigades: a tale of blood, ideals and tragedy in the fight against fascism. The Spanish Civil War was the first armed battle in the fight against fascism, and a rallying cry for a generation. Over 35,000 volunteers from sixty-one countries around the world came to defend democracy against the troops of Franco, Hitler and Mussolini. Ill-equipped and disorderly, yet fuelled by a shared sense of purpose and potential glory, these disparate groups of idealistic young men and women formed a volunteer a...
Believing that everything has a precedent, Chinese artists were never bashful about reproducing art, typically seeing less of a difference between the original work and reproductions. As a result, replication has often been considered a fundamental mode of production in Chinese art, with roots extending to antiquity. In turn, some collectors would knowingly brandish originals next to replicas while others completely rejected the idea of imitations as artworks. This book explores the controversial questions of faking, copying, and replicating Chinese painting, bronzes, ceramics, works on paper, and sculpture.
About: Detailed discussion of the fundamental aspects of electrophysiology and includes over 70 case studies from an internationally recognzed group of contributors covering ECGs, SVTs, atrial fibrillation, ventricular tachycardia and more. Includes major contributions from Samuel Asirvatham, MD and Hein J. Wellens, MD. From the Preface: A plethora of significant new research and findings makes it difficult to keep up with the ever-changing field of electrophysiology. Despite these constant advances, there are fundamental aspects of the science that need to be understood by students of electrophysiology. This book was created to educate and uses cases and questions to keep the reader engaged. Chapter and case topics were chosen so that the information presented is useful for years to come. My associate editors and I are hopeful that this book will prove a useful tool for those interested in the field of electrophysiology. We also are very grateful to all the contributing authors for spending their time and effort to help create this handy but comprehensive and interesting work. Jasbir Sra, Milwaukee
A classic and definitive work on cyclopean perception that has influenced vision researchers, cognitive scientists, neuroscientists, artists, designers, and computer graphics pioneers traces the information flow in the visual system.
Efforts to relate neuroscience and anatomy with ethology and psychology have involved an ever widening group of scientists from diverse backgrounds and it has become increasingly evident that interaction is harder to arrange. This book is offered as a first attempt to address some of these interdisciplinary problems. First, it aims to provide a critical evaluation of some of the principal methods used by neuropsychologists in research and assessment. Second, it provides short evaluations of the methods which they use to shed further light on brain dysfunction. In this way it is hoped that it offers a further insight into this multidisciplinary field.
Making a neighborhood of a nation -- Professor Morse's lightning -- Antimonopoly -- The new postalic dispensation -- Rich man's mail -- The talking telegraph -- Telephomania -- Second nature -- Gray wolves -- Universal service -- One great medium?