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Fibrogenesis
Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options. The chapters in this book have been selected to provide comprehensive information on fibrogenesis, which is not limited to any specific organ. Individual chapters present mechanisms of fibrotic diseases involving lung, liver, kidney, heart, blood vessels, and more. The relevance and significance of inflammatory cytokines, chemokines, transcriptional factors, fibrogenic molecules, signaling cascade, and matrix remodeling in fibrogenesis are explained in depth, providing the reader with current and updated information.
Freedom's Main Line
“A compelling, spellbinding examination of a pivotal event in civil rights history . . . a highly readable and dramatic account of a major turning point.” —Journal of African-American History Black Americans in the Jim Crow South could not escape the grim reality of racial segregation, whether enforced by law or by custom. In Freedom’s Main Line: The Journey of Reconciliation and the Freedom Rides, author Derek Charles Catsam shows that courtrooms, classrooms, and cemeteries were not the only front lines in African Americans’ prolonged struggle for basic civil rights. Buses, trains, and other modes of public transportation provided the perfect means for civil rights activists to pr...
Phosphate and Vitamin D in Chronic Kidney Disease
The enormous progress made during the last decade has resulted in a better conceptual understanding of mineral ion metabolism in general. With regard to chronic kidney disease, the two most affected nutrients are phosphate and vitamin D. This book provides an overview of the physiological aspects of phosphate and vitamin D metabolism, and how their pathological dysregulation facilitates advancement of chronic kidney disease. It looks into the complex molecular and organ cross-talks during disease progression that range from the involvement of fibroblast growth factor (FGF23)-klotho system to impaired phosphate transport to hormonal dysfunctions of PTH and vitamin D. Each chapter clearly presents the clinically and biologically important problems and lists the key unsolved issues related to chronic kidney disease and beyond. Illustrations explaining multi-factorial and multi-organ interactions provide an easy outline for the reader to appreciate the complex biological pathways. For those without prior familiarity with the subject matter, this volume may serve as a quick reference to get updated information on phosphate and vitamin D metabolism.
Adverse Childhood Experiences
The entire world is in crisis with adverse childhood experiences (ACEs) and other lifetime trauma at an all-time high. This book is a valuable resource to promote optimal brain function for everyone, but especially for survivors of trauma who are particularly at risk throughout the life course. It is critical for healthcare providers, schoolteachers and administration, public safety professionals, foster and adoptive parents, employers and loved ones to understand the potential life-long consequences that ACEs can have in the lives of survivors. This book describes the complexities behind why behaviors occur if hurt people hurt themselves and others. The first half of this book addresses wha...
Doctoral Dissertations on South Asia, 1966–1970
This volume gathers the harvest of recent doctoral dissertations on South Asia, principally from North America and Western Europe, but exclusive of theses from universities in South Asia itself. The yield—1305 dissertations based on research carried out during the early and middle nineteen-sixties and brought to completion between 1966 and 1970—is even greater than one would have guessed, eloquent testimony to the expansion of South Asian studies in the West over the last decade. Doctoral Dissertations on South Asia seeks to be a comprehensive compilation of recently completed theses dealing in whole or in part with the former civilizations and the contemporary affairs of Ceylon, India, Nepal and Pakistan. At the same time, this work provides striking testimony of the dynamic growth of Asian Studies outside the subcontinent and particularly in the United States, Great Britain, Germany and France, where most of the major centers of scholarship are presently found. It is an interdisciplinary work covering the natural sciences as well as the humanities and social sciences.
Political Argument
Political Argument guides students through the process of crafting fact-based arguments in political science using logic and sound research.
Games and Learning Alliance
This book constitutes the refereed proceedings of the 9th International Conference on Games and Learning Alliance, GALA 2020, held in Laval, France, in December 2020. The 35 full papers and 10 short papers were carefully reviewed and selected from 77 submissions. The papers cover a broad spectrum of topics: Serious Game Design; Serious Game Analytics; Virtual and Mixed Reality Applications; Gamification Theory; Gamification Applications; Serious Games for Instruction; and Serious Game Applications and Studies.
