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Control of Biofilm Infections by Signal Manipulation
The number of patients affected by and dying from what can be considered as a "biofilm disease" is higher than heart disease and cancer combined. Thus, this is a hugely important work that describes the molecular mechanisms of cell-to-cell communication among bacterial cells in a biofilm, the development of antibiofilm inhibitors such as quorum-sensing inhibitors, and the use of biofilm inhibitors to prevent and treat bacterial infections in humans and other animals.
Biofilm Highlights
Living in biofilms is the common way of life of microorganisms, transiently immobilized in their matrix of extracellular polymeric substances (EPS), interacting in many ways and using the matrix as an external digestion and protection system. This is how they have organized their life in the environment, in the medical context and in technical systems – and has helped make them the oldest, most successful and ubiquitous form of life. In this book, hot spots in current biofilm research are presented in critical and sometimes provocative chapters. This serves a twofold purpose: to provide an overview and to inspire further discussions. Above all, the book seeks to stimulate lateral thinking.
The Handy Astronomy Answer Book
Unraveling the Mysteries of the Night Sky. Fact-filled and image-rich guide to the principles of astronomy, its history, a host of fun facts, and helpful tips for the backyard or budding astronomers! We look to the heavens and wonder in awe. Shooting stars, constellations, planets, galaxies, and the unknown. What is out there? Who is out there? How did the stars and planets come to be? What does it all mean? The last few years have brought an explosion of information leading to serious consideration of questions once deemed crazy. Do other universes exist? Are there planets that could harbor life? From a neutron star to a black hole; from the Higgs Boson particle to cosmic strings; from the ...
The Handy Art History Answer Book
The Art of Discovery. The Discovery of Art. The History of Art! Warhol, Michelangelo, and da Vinci. Picasso, Monet, and Rembrandt, Ai WeiWei and Jenny Holzer. What were they thinking when they created their masterworks? While we can't always know an artist's exact thoughts, The Handy Art History Answer Book examines their benefactors, their wealth or poverty, their passions, the politics, and the world events that inspired and influenced them. Explore their techniques and materials, the forms, colors and styles, the movements and schools of thoughts, and discover the varied forms and nature of artistic expression. Tracing art history from cave paintings to contemporary installations, along w...
The Handy Physics Answer Book
Eschewing the usual mathematical explanations for physics phenomena, this approachable reference explains complicated scientific concepts in plain English that everyone can understand. Tackling the big issues such as gravity, magnetism, sound, and what really happens in the Large Hadron Collider, this engaging look at physics also spells out why cats always land on their feet, why people appear to have red eyes in photographs, and the real danger of looking at an eclipse. For everyone who ever wondered how a light bulb works or how squirrels avoid electrocution on the power lines, this handbook supplies answers on the physics of everyday life and examines the developments in the exploration of subatomic particles. In addition to the question-and-answer section, an addendum of facts about physicists explains what the Nobel prize is and who has won it, and tells the story of the scientist who was incarcerated for agreeing with Copernicus. Answers more than eight hundred questions about physics, ranging from everyday life applications to the latest explorations in the field.
The Handy Chemistry Answer Book
Don't be mixed up about chemistry! Simplify the complex chemical reactions that take place everywhere in our lives with this engaging, easy-to-follow, question-and-answer guide! Where would we be without atoms and compounds? Gas, liquids, solids, and plasma? Acids and bases? Bonds and reactions? Matter and energy? The Handy Chemistry Answer Book covers the building blocks of life and the universe. The secret life of atoms, how polar bears aren’t actually white, why oil and water don't mix, and much, much more are revealed and explained. This informative guide covers the basics of chemistry (history, atomic structures, chemical bonds and reactions, organic and inorganic chemistry) to more a...
Signal Transduction and Bacterial Virulence
In order to survive, bacteria must constantly monitor their structure and physiology. Adaptive behaviours are established by using environmental sensors and response regulators. These communication modules regulate a wide variety of signals including host detection and invasion, cell cycle, metabolite utilization, starvation and many others. The purpose of this volume is to give an overview of the various systems and to introduce recent advances in understanding selected systems of pathogenic bacteria.
The Handy Philosophy Answer Book
Plato, Aristotle, Nietzsche, Sartre, and many more. Who were they? What did they say? Why should we care? How did changing philosophical thought affect the history of civilization? How does philosophy affect pop culture, politics and government, and our everyday lives? Combining a basic history of philosophical thought with the often quirky personal stories of famous philosophers, The Handy Philosophy Answer Book introduces the reader to the world of philosophy. This comprehensive survey analyzes the collective effort of philosophers throughout history in the pursuit of truth and wisdom. It explores the tangible significance of philosophical thought to modern society and civilization as a wh...
The Handy Christianity Answer Book
Engaging answers to common questions on the history, beliefs, practices and what it means to be a Christian. What does it mean to be a Christian? What is the core of the faith? What does it mean to follow the gospel? What is the significance of the rites, rituals, and symbols of Christianity, such as baptism and the crucifix? Who was Jesus Christ and what was His life like? How did Christianity start, spread, and grow? What are the differences—and similarities—between Roman Catholicism, Eastern Orthodoxy, and Protestantism? How did Christianity influence art, architecture, music, and movies? The Handy Christianity Answer Book provides detailed descriptions of the teachings of Jesus, Chri...
