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Intestinal Differentiated Cells
This volume details the most up-to-date methods of intestinal differentiation program. Chapters guide readers through techniques to characterize intestinal differentiated cell, RNAseq, single-cell RNAseq transcriptional profiling methods, isolation of intestinal crypts, and methods for studying intestinal differentiated cancer cells. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Intestinal Differentiated Cells: Methods and Protocols aims to be comprehensive guide for researchers.
Gynaecological Malignancies
“Gynaecological Malignancies - Updates and Advances” aims to present a review of the significant advances in the understanding and management of gynaecological malignancies. Major areas of importance in this field will be covered, incorporating new knowledge that has arisen due to the advancements in molecular techniques and the ability to correlate these molecular changes with clinical behaviour of gynaecologic tumours. The therapeutic implications of molecular subtyping to match appropriate therapies and the appreciation of the use of up to date radiotherapy techniques will be explored.
Nuclear Receptors as Drug Targets
Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.
Telomeres and Telomerase in Cancer
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
Planning, Development and Management of Sustainable Cities
The concept of ‘sustainable urban development’ has been pushed to the forefront of policymaking and politics as the world wakes up to the impacts of climate change and the destructive effects of the Anthropocene. Climate change has emerged to be one of the biggest challenges faced by our planet today, threatening both built and natural systems with long-term consequences, which may be irreversible. While there is a vast body of literature on sustainability and sustainable urban development, there is currently limited focus on how to cohesively bring together the vital issues of the planning, development, and management of sustainable cities. Moreover, it has been widely stated that curre...
Protected Landscapes and Cultural and Spiritual Values
Documents, using case studies, the non-material values that are to be found in protected landscapes.
Minerals of Mexico
After many years of geographical and bibliographical journeys, William Panczner has completed a project that many of us would have loved to initiate, but did not undertake because of its magnitude and intrinsic complexity. Not since L. Salazar Salinas, who is credited with authoring Bole tin numeros 40 and 41 (lnstituto Geologico de Mexico, 1922, 1923), has an author been able to provide readers with a comprehensive volume containing information that is both authentic and reliable on Mexican mineralogy, mineral species, and localities. This volume is the most complete synthesis about Mexican minerals and their occurrences to date. It is richly illustrated with photographs and drawings, is we...
Therapeutic and Nutritional Uses of Algae
Algae have been used since ancient times as food, fodder, fertilizer and as source of medicine. Nowadays seaweeds represent an unlimited source of the raw materials used in pharmaceutical, food industries, medicine and cosmetics. They are nutritionally valuable as fresh or dried vegetables, or as ingredients in a wide variety of prepared foods. In particular, seaweeds contain significant quantities of protein, lipids, minerals and vitamins. There is limited information about the role of algae and algal metabolites in medicine. Only a few taxa have been studied for their use in medicine. Many traditional cultures report curative powers from selected alga, in particular tropical and subtropica...
The Change Laboratory
The Change Laboratory is a method for formative intervention in work communities that supports this kind of organizational learning. It is a path breaker in the area of work place learning due to its strong theoretical and research basis and the way that it integrates the change of organizational practices and individuals’ learning. It provides a way to develop practitioners’ transformative agency and capacity for creating and implementing new conceptual and practical tools for mastering their joint activity.
