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Algebraic and Combinatorial Computational Biology
Algebraic and Combinatorial Computational Biology introduces students and researchers to a panorama of powerful and current methods for mathematical problem-solving in modern computational biology. Presented in a modular format, each topic introduces the biological foundations of the field, covers specialized mathematical theory, and concludes by highlighting connections with ongoing research, particularly open questions. The work addresses problems from gene regulation, neuroscience, phylogenetics, molecular networks, assembly and folding of biomolecular structures, and the use of clustering methods in biology. A number of these chapters are surveys of new topics that have not been previous...
Mathematical Concepts and Methods in Modern Biology
Mathematical Concepts and Methods in Modern Biology offers a quantitative framework for analyzing, predicting, and modulating the behavior of complex biological systems. The book presents important mathematical concepts, methods and tools in the context of essential questions raised in modern biology.Designed around the principles of project-based learning and problem-solving, the book considers biological topics such as neuronal networks, plant population growth, metabolic pathways, and phylogenetic tree reconstruction. The mathematical modeling tools brought to bear on these topics include Boolean and ordinary differential equations, projection matrices, agent-based modeling and several algebraic approaches. Heavy computation in some of the examples is eased by the use of freely available open-source software. - Features self-contained chapters with real biological research examples using freely available computational tools - Spans several mathematical techniques at basic to advanced levels - Offers broad perspective on the uses of algebraic geometry/polynomial algebra in molecular systems biology
Algebraic and Discrete Mathematical Methods for Modern Biology
Written by experts in both mathematics and biology, Algebraic and Discrete Mathematical Methods for Modern Biology offers a bridge between math and biology, providing a framework for simulating, analyzing, predicting, and modulating the behavior of complex biological systems. Each chapter begins with a question from modern biology, followed by the description of certain mathematical methods and theory appropriate in the search of answers. Every topic provides a fast-track pathway through the problem by presenting the biological foundation, covering the relevant mathematical theory, and highlighting connections between them. Many of the projects and exercises embedded in each chapter utilize ...
Laboratory Manual of Biomathematics
Laboratory Manual of Biomathematics is a companion to the textbook An Invitation to Biomathematics. This laboratory manual expertly aids students who wish to gain a deeper understanding of solving biological issues with computer programs. It provides hands-on exploration of model development, model validation, and model refinement, enabling students to truly experience advancements made in biology by mathematical models. Each of the projects offered can be used as individual module in traditional biology or mathematics courses such as calculus, ordinary differential equations, elementary probability, statistics, and genetics. Biological topics include: Ecology, Toxicology, Microbiology, Epid...
An Invitation to Biomathematics
Essential for all biology and biomathematics courses, this textbook provides students with a fresh perspective of quantitative techniques in biology in a field where virtually any advance in the life sciences requires a sophisticated mathematical approach. An Invitation to Biomathematics, expertly written by a team of experienced educators, offers students a solid understanding of solving biological problems with mathematical applications. This text succeeds in enabling students to truly experience advancements made in biology through mathematical models by containing computer-based hands-on laboratory projects with emphasis on model development, model validation, and model refinement. The s...
Laboratory Manual of Biomathematics
Laboratory Manual of Biomathematics is a companion to the textbook An Invitation to Biomathematics. This laboratory manual expertly aids students who wish to gain a deeper understanding of solving biological issues with computer programs. It provides hands-on exploration of model development, model validation, and model refinement, enabling students to truly experience advancements made in biology by mathematical models. Each of the projects offered can be used as individual module in traditional biology or mathematics courses such as calculus, ordinary differential equations, elementary probability, statistics, and genetics. Biological topics include: Ecology, Toxicology, Microbiology, Epid...
An Invitation to Biomathematics
This textbook provides students with a fresh perspective of quantitative techniques in biology in a field where virtually any advance in the life sciences requires a sophisticated mathematical approach. It is written by a team of experienced educators, and offers students a solid understanding of solving biological problems with mathematical applications. It succeeds in enabling students to truly experience advancements made in biology through mathematical models by containing computer-based hands-on laboratory projects with emphasis on model development, model validation, and model refinement.
Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer
Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options. Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease...
Quantitative Biology: Dynamics of Living Systems
With the emergence of Systems Biology, there is a greater realization that the whole behavior of a living system may not be simply described as the sum of its elements. To represent a living system using mathematical principles, practical quantities with units are required. Quantities are not only the bridge between mathematical description and biological observations; they often stand as essential elements similar to genome information in genetics. This important realization has greatly rejuvenated research in the area of Quantitative Biology. Because of the increased need for precise quantification, a new era of technological development has opened. For example, spatio-temporal high-resolu...
