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This volume provides an overview of the latency strategies developed during the estimated 200,000 year-long coevolution of Alpha-, Beta- and Gammaherpesvirinae and their host species. While the main emphasis is on herpesviruses infecting humans, relevant cases if herpesviruses infecting animals are covered as well. Special emphasis is given to results on molecular mechanisms regulating latent promoters of herpesvirus genomes and signals and molecular pathways resulting in reactivation of latent viral genomes.
*pithy bullet points and standard prose allow the reader to assimilate concepts and key messages with ease. *summary tables, neuroimages, photomicrographs, neuroanatomic drawings, gross and microscopic neuropathologic specimen photos, graphics and summary boxes further enhance the text. * chapters are crafted in a way to appeal to both the visuo-spatial and analytic functional centers of the brain, as we stimulate the senses and learn.
Since the publication of the highly successful first edition, there has been an explosion of rigorous scientific evidence for interventions in clinical neurology. Hankey's Clinical Neurology, Second Edition is fully updated to accommodate the latest advancements in clinical neuroscience. Designed for students of clinical neurology, neurologists-in-training, and practicing neurologists who need ready access to a comprehensive, evidence-based guide to new and notable neurologic disorders, the Second Edition: Contains a chapter solely dedicated to sleep disorders Introduces a section on neuro-ophthalmology within the cranial neuropathies chapter Reflects a more global approach, as each chapter ...
Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including "targeted agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease. Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus fa...
This issue of Neurologic Clinics, guest edited by Dr. José Biller, is devoted to Therapy in Neurology. This issue is one of four selected each year by the series Consulting Editor, Dr. Randolph W. Evan. Articles in this issue include: Update on CGRP Antagonism in the Treatment of Migraine, Advances in the Treatment of Multiple Sclerosis, Advances in the Treatment of Neuromyelitis Optica Spectrum Disorder, Advances and ongoing controversies in PFO closure and cryptogenic stroke, Advances in neuromodulation/neurostimulation in Neurology, Advances in the treatment of muscular dystrophies and motor neuron disorders, Advances in the management of small fiber neuropathies, Update in the treatment of Idiopathic Intracranial Hypertension, What is new in neuro-oncology?, Advances in the surgical management of epilepsy, Treatment of Viral Encephalitis, An update on Botulinum toxin in neurology, Cannabinoids in neurological illnesses, and Pitfalls in Transitioning Neurological Care of the Developmentally Disabled from Pediatric to Adult Providers.
A state-of-the-art resource on current and future advances in the treatment of intradural spinal tumors Tumors of the spinal canal provide unique challenges in terms of surgical approaches and oncological treatment. Management requires in-depth knowledge of the intricate anatomical relationships between the tumors and normal spinal pathways, restricted corridors of entry, and limitations of drug penetration. Over the past few decades, significant strides have been made in the treatment of these tumors. Development of minimally invasive techniques and greater understanding of these pathologies has resulted in improved safety, precision, and outcomes. Tumors of the Spinal Canal: Surgical Appro...