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An Introduction to Systems Biology
Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
An Introduction to Systems Biology
Praise for the first edition: ... superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. – Nature [This text deserves] serious attention from any quantitative scientist who hopes to learn about modern biology ... It assumes no prior knowledge of or even interest in biology ... One final aspect that mu...
An Introduction to Systems Biology
Praise for the first edition: ... superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. – Nature [This text deserves] serious attention from any quantitative scientist who hopes to learn about modern biology ... It assumes no prior knowledge of or even interest in biology ... One final aspect that mu...
Handbook of Graphs and Networks
Complex interacting networks are observed in systems from such diverse areas as physics, biology, economics, ecology, and computer science. For example, economic or social interactions often organize themselves in complex network structures. Similar phenomena are observed in traffic flow and in communication networks as the internet. In current problems of the Biosciences, prominent examples are protein networks in the living cell, as well as molecular networks in the genome. On larger scales one finds networks of cells as in neural networks, up to the scale of organisms in ecological food webs. This book defines the field of complex interacting networks in its infancy and presents the dynam...
Phosphate in Paediatric Health and Disease
Phosphate in Pediatric Health and Disease provides a state-of-the-art overview of normal physiology, pathophysiology, genetics, clinical and therapeutic aspects of different types of phosphate homeostasis in early life. The book reviews the developmental physiology of phosphate metabolism from the fetus to the adolescent. It describes the pathophysiologic mechanisms associated with perturbations in phosphate homeostasis as well as discusses the different clinical conditions related to abnormal mineral metabolism, parathyroid hormone and vitamin D in infancy, childhood, and adolescence, and the modern diagnostic and therapeutic modalities. This book will benefit pediatricians, endocrinologists, neurologists, nutritionists, and researchers in the field of mineral metabolism.
Biological Computation
The area of biologically inspired computing, or biological computation, involves the development of new, biologically based techniques for solving difficult computational problems. A unified overview of computer science ideas inspired by biology, Biological Computation presents the most fundamental and significant concepts in this area. In the book
Treated Wastewater in Agriculture
As the world's population increases and the demand for water increases apace there is a rising demand for information concerning the reuse of wastewater, particularly for the irrigation of key food crops worldwide. This important new book addresses in detail the use of treated wastewater in agricultural situations, its impact on crops and the soil environment. Coverage includes the composition and treatment of wastewater, health considerations, regulations and economic aspects. Major sections of the book also concentrate on crop management and the soil environment. This book is an essential purchase for all those working in irrigation, water management and crop production worldwide. Use of Treated Wastewater (TWW) for irrigation is increasingly important as the world's population increases Chapters prepared by leading scientists in the field Comprehensive coverage of current knowledge and advances in the area of TWW Focus on possible environmental impacts (positive and negative)
Systems Biology of Cell Signaling
How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destructio...
Lexical Acquisition
On-line information -- and free text in particular -- has emerged as a major, yet unexploited, resource available in raw form. Available, but not accessible. The lexicon provides the major key for enabling accessibility to on-line text. The expert contributors to this book explore the range of possibilities for the generation of extensive lexicons. In so doing, they investigate the use of existing on-line dictionaries and thesauri, and explain how lexicons can be acquired from the corpus -- the text under investigation -- itself. Leading researchers in four related fields offer the latest investigations: computational linguists cover the natural language processing aspect; statisticians point out the issues involved in the use of massive data; experts discuss the limitations of current technology; and lexicographers share their experience in the design of the traditional dictionaries.
