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Computational Approaches for Identifying Drugs Against Alzheimer's Disease
Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function o...
Spirit Junkie
“So long, Carrie Bradshaw—there’s a new role model for go-getting thirty-somethings. Gabrielle Bernstein is doling out inner peace and self-love for the postmodern spiritual set.”—Elle Foreword by Marianne Williamson Before she became a celebrated teacher and lecturer, Gabrielle Bernstein was going down a dangerous path. For years, Bernstein struggled with eating disorders, drug and alcohol abuse, and constant self-doubt and self-loathing. That all changed when she discovered A Course in Miracles, which taught her that much of what she feared in life was not frightening at all and, in many cases, not even real. Now, Bernstein lives an empowered, healthy, and joyful life. In Spirit ...
Get Out of That Pit: Straight Talk about God's Deliverance
From her first breath of fresh air beyond the pit, it has never been enough for Beth Moore to be free. This best-selling author and Bible teacher who has opened the riches of Scripture to millions longs for you to be free as well—to know the Love and Presence that are better than life and the power of God’s Word that defies all darkness. Beth’s journey out of the pit has been heart-rending. But from this and the poetic expressions of Psalm 40 has come the reward: a new song for her soul, given by her Saviour and offered to you in Get Out of That Pit—friend to friend. This is Beth’s most stirring message yet of the sheer hope, utter deliverance, and complete and glorious freedom of God: I waited patiently for the Lord He turned to me and heard my cry He lifted me out of the slimy pit He set my feet on a rock He put a new song in my mouth It is a story, a song—a salvation—that you can know too.
A Short Philosophy of Birds
The greatest wisdom comes from the smallest creatures There is so much we can learn from birds. Through twenty-two little lessons of wisdom inspired by how birds live, this charming french book will help you spread your wings and soar. We often need the help from those smaller than us. Having spent a lifetime watching birds, Philippe and Élise – a French ornithologist and a philosopher – draw out the secret lessons that birds can teach us about how to live, and the wisdom of the natural world. Along the way you’ll discover why the robin is braver than the eagle, what the arctic tern can teach us about the joy of travel, and whether the head or the heart is the best route to love (as shown by the mallard and the penguin). By the end you will feel more in touch with the rhythms of nature and have a fresh perspective on how to live the fullest life you can.
Sedução Astral
Você sabe qual é a relação entre a Astrologia e o amor? Além de influenciar a personalidade de uma pessoa, os astros mostram o que precisa ser explorado quando o assunto é conquista, sedução e encantamento. A maioria das pessoas sabe algo sobre seu signo, mas poucas sabem como ele se comporta no amor, na arte da sedução, quais as características mais favoráveis para conquistar alguém. Este livro revela chaves secretas, baseadas na Astrologia e na moda, para atrair quem você deseja e encontrar seu par perfeito.
The Physics of Cancer
An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.
Mediocracy
There was no Reichstag fire. No storming of the Bastille. No mutiny on the Aurora. Instead, the mediocre have seized power without firing a single shot. They rose to power on the tide of an economy where workers produce assembly-line meals without knowing how to cook at home, give customers instructions over the phone that they themselves don’t understand, or sell books and newspapers that they never read. Canadian intellectual juggernaut Alain Deneault has taken on all kinds of evildoers: mining companies, tax-dodgers, and corporate criminals. Now he takes on the most menacing threat of all: the mediocre.
Punks: New & Selected Poems
A landmark collection of poetry by acclaimed fiction writer, translator, and MacArthur Fellow John Keene, PUNKS: NEW & SELECTED POEMS is a generous treasury in seven sections that spans decades and includes previously unpublished and brand new work. With depth and breadth, PUNKS weaves together historic narratives of loss, lust, and love. The many voices that emerge in these poems--from historic Black personalities, both familial and famous, to the poet's friends and lovers in gay bars and bedrooms--form a cast of characters capable of addressing desire, oppression, AIDS, and grief through sorrowful songs that "we sing as hard as we live." At home in countless poetic forms, PUNKS reconfirms ...
Karloff and the East
Among Golden Age Hollywood film stars of European heritage known for playing characters from the East--Chinese, Southeast Asians, Indians and Middle Easterners--Anglo-Indian actor Boris Karloff had deep roots there. Based on extensive new research, this biography and career study of Karloff's "eastern" films provides a critical examination of 41 features, including many overlooked early roles, and offers fresh perspective on a cinematic luminary so often labeled a "horror icon." Films include The Lightning Raider (1919), 14 silent films from the 1920s, The Unholy Night (1929), The Mask of Fu Manchu (1932), The Mummy (1932), John Ford's The Lost Patrol (1934), the Mr. Wong series (1938-1940), Targets (1968), and Isle of the Snake People (1971), one of six titles released posthumously.
