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Vegf and Cancer
VEGF and Canceris a comprehensive and up to date review of current knowledge on the role of vascular endothelial growth factor (VEGF) in cancer. Key Features: -Discussion of VEGF as potent angiogenic factor and its role in tumor angiogenesis, -Review of the biology, molecular properties and regulation of VEGF, -Discussion of the role of VEGF in a range of different tumor types, both solid tumors and haematological cancers, -Review of the therapeutic potential of different approaches to block VEGF, -Review of recent evidence that in addition to its role as an endothelial cell mitogen, VEGF may also be an autocrine growth factor for tumor cells, regulating survival and invasion. This book is aimed at scientists new to angiogenesis and VEGF biology and provides new information for established researchers and scientists. It will also be a useful text for clinicians interested in anti-angiogenic therapy for treatment of human cancers.
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Defining Americans
Andrew Jackson spoke to Americans in ways that reflected the concerns of a young nation. Grover Cleveland helped citizens redefine themselves after the havoc of the Civil War era. FDR confronted widespread hardship with hope and determination, while Eisenhower spoke to our fears of the Communist menace. Throughout our history, presidents by their very utterances have shaped our sense of who we are as Americans. As Mary Stuckey observes, presidents embrace, articulate, and reinvigorate our sense of national identity. They define who Americans are—often by declaring who they aren’t. In this book, she shows how presidential speech has served to broaden the American political community over ...
Vascular-Targeted Therapies in Oncology
Vascular-Targeted Therapies in Oncology provides an interesting insight to the current status and future potential of vascular-disrupting approaches in cancer management. Emphasis is placed on target development, preclinical assessment, and the use of such targeted approaches in combination with conventional treatment regimens and the current clinical status of these therapies.
Women of the Mountain South
Scholars of southern Appalachia have largely focused their research on men, particularly white men. While there have been a few important studies of Appalachian women, no one book has offered a broad overview across time and place. With this collection, editors Connie Park Rice and Marie Tedesco redress this imbalance, telling the stories of these women and calling attention to the varied backgrounds of those who call the mountains home. The essays of Women of the Mountain South debunk the entrenched stereotype of Appalachian women as poor and white, and shine a long-overdue spotlight on women too often neglected in the history of the region. Each author focuses on a particular individual or group, but together they illustrate the diversity of women who live in the region and the depth of their life experiences. The Mountain South has been home to Native American, African American, Latina, and white women, both rich and poor. Civil rights and gay rights advocates, environmental and labor activists, prostitutes, and coal miners—all have lived in the place called the Mountain South and enriched its history and culture.
Angiogenesis Assays
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and...
The Black Christ of Esquipulas
On the eastern border of Guatemala and Honduras, pilgrims and travelers flock to the Black Christ of Esquipulas, a large statue carved from wood depicting Christ on the cross. The Catholic shrine, built in the late sixteenth century, has become the focal point of admiration and adoration from New Mexico to Panama. Beyond being a site of popular devotion, however, the Black Christ of Esquipulas was also the scene of important debates about citizenship and identity in the Guatemalan nation throughout the nineteenth and twentieth centuries. In The Black Christ of Esquipulas, Douglass Sullivan-González explores the multifaceted appeal of this famous shrine, its mysterious changes in color over ...
Writing Southern Politics
Scholars, journalists, writers, and pundits have long regarded the South as the nation's most politically distinctive region. Its culture, history, and social and economic institutions have fostered unique political ideas that intrigue observers and have had profound political consequences for the nation's citizens, politicians, and policymakers. Writing Southern Politics is the most comprehensive review of the large body of post–World War II literature on southern politics. Since the publication of V.O. Key Jr.'s landmark work, Southern Politics in State and Nation (1949), scholars have produced an astounding number of books, monographs, professional journal articles, and research papers ...
Heritage and Hate
"Explores how Ole Miss and other Southern universities presently contend with an inherited panoply of Southern words and symbols and "Old South" traditions, everything that publicly defines these communities--from anthems to buildings to flags to monuments to mascots"--
