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Studies in Natural Products Chemistry, Volume 83 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores
A obra oferece introspecções intelectuais e extrospecções didáticas dos autores nas diversas áreas do conhecimento imersos nos fazeres docentes e aprendizagens discentes enquanto resultados de pesquisas e experiências educacionais. Com isso, o estudo exarado nos capítulos, a presente publicação contribui com textos que versam de algum modo, direta ou indiretamente, a educação e o ensino numa perspectiva da teoria ou pela prática pedagógica com a intenção de trazer ideias interdisciplinares e questionamentos para incentivar o debate a respeito do ensino e da aprendizagem. Tudo isso se revela por meio de novos e múltiplos olhares interdisciplinares na educação e articulados pelos conhecimentos teóricos aos práticos, possibilitando ampliar e significar os múltiplos saberes para Pensar e Fazer a Educação.
Misha Glenny's groundbreaking study of global organized crime is now the inspiration for an 8-part AMC crime drama starring James Norton (War and Peace), Juliet Rylance, and David Strathairn. With the collapse of the Soviet Union, the fall of the Berlin Wall, and the deregulation of international financial markets in 1989, governments and entrepreneurs alike became intoxicated by dreams of newly opened markets. But no one could have foreseen that the greatest success story to arise from these events would be the worldwide rise of organized crime. Today, it is estimated that illegal trade accounts for one-fifth of the global GDP. In this fearless and wholly authoritative investigation of the seemingly insatiable demand for illegal wares, veteran reporter Misha Glenny travels across five continents to speak with participants from every level of the global underworld--police, victims, politicians, and even the criminals themselves. What follows is a groundbreaking, propulsive look at an unprecedented phenomenon from a savvy, street-wise guide.
This book highlights recently discovered aspects of “middle-size molecules,” focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for π-conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science.
The present book consists of three parts: discovery, development and production of drugs from marine organisms. Marine bacteria, fungi, microalgae, sponges and opisthobranch mollusks have attracted much attention as sources of potential drugs, which is described in the first part. A pain-killing drug developed from the venom of a cone shell is a recent highlight of marine natural product research; the interesting story of its discovery is provided. The second part features an anticancer drug with a novel mode of action which was originally isolated from a songe and a potential antiosteoporotic drug of a hexacoral origin. But the most serious problem for development of drugs from the sea remains supply. Two possible solutions, production by fermentation and by aquaculture, are described in the third part. Identification and culture of symbiotic bacteria which are responsible for the production of bioactive sponge metabolites are the main objectives for many researchers.
Biotechnological Production of Bioactive Compounds provides insights on the most recent innovations, trends, concerns, solutions and practical challenges encountered in the fields of enzyme technology and nanobiotechnology for the production of bioactive materials with extra health benefits. As nanobiotechnology has improved the bioactive extraction process significantly, many bioactives, including bioflavonoids, omega-3 fatty acids, biopigments and low calorie sugar substitutes are a pivotal part of the food industry. The book highlights the production of extra health benefits "bioactives'' from plants and microbes and explains how the extraction efficiency of bioactives molecules improves ...
This book offers test-taking tips, diagnostic tests, review, and practice exams with answers and detailed explanations for all portions of the NCLEX-RN exam.
"This book offers a short, spirited defense of rhetoric and the liberal arts as catalysts for precision, invention, and empathy in today's world. The author, a professor of Shakespeare studies at a liberal arts college and a parent of school-age children, argues that high-stakes testing and a culture of assessment have altered how and what students are taught, as courses across the arts, humanities, and sciences increasingly are set aside to make room for joyless, mechanical reading and math instruction. Students have been robbed of a complete education, their imaginations stunted by this myopic focus on bare literacy and numeracy. Education is about thinking, Newstok argues, rather than the...
All-new clinical resource for managing children with developmental and behavioral concerns. Developed by leading experts in developmental and behavioral pediatrics, the all-new AAP Developmental and Behavioral Pediatrics gives one place to turn for expert recommendations to deliver, coordinate, and/or monitor quality developmental/behavioral care within the medical home. The one resource with all the essentials for pediatric primary care providers. Evaluation and care initiation: Interviewing and counseling, Surveillance and screening, Psychoeducational testing, Neurodevelopment.