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Advances in Molecular Biology Knowledge of Rectal Cancer and Forthcoming Role of Liquid Biopsy
The treatment algorithm of locally advanced rectal cancer has been changing in the last years and a multidisciplinary approach is required to select effective and personalized treatment. Nowadays, total neoadjuvant treatment is an established validated strategy for high-risk rectal cancer patients as it showed and has shown increased complete response rate representing a new standard of care. Therefore, the selection of predictive molecular markers is, even more, an essential and pursued medical needs goal. Moreover, regarding the early stage of disease, one major question pertains to the risk of recurrence and minimal residual disease: when is staging based on pathologic features adequate for a shared therapeutic decision? This is one of the main issues concerning future advances.
The Thorax
This book highlights the differences, in terms of neoplastic dissemination pathways, between various types of thoracic cancers. It presents and discusses a comprehensive schematic overview of tumors of the lung parenchyma, of the mediastinum, of the pleura, and of the chest wall. For each tumor, it details the local spread and the lymphatic and vascular dissemination, and it describes the challenging staging of lung tumors with mutations. Illustrations and artwork enrich the content and help readers to understand and visualize tumor spread. The book is of great interest to professionals involved in the study, diagnosis and treatment of thoracic pathologies, as well as to residents in radiology, oncology and pulmonology.
Molecular targets for the treatment of metastatic colorectal cancer
description not available right now.
Forensic Pathology Case Studies
Forensic Pathology Case Studies features 8-13 case studies from the author's 19-year career as both a forensic pathologist and anthropologist in northern Italy. Every case will be presented as an extended version of a professional report, where the descriptions of circumstances, the scientific approach to investigation techniques, their results, the critical interpretation of results, and the case resolution are combined. Photos are available for most cases and will help clarifying the cases to the reader. References will inspire further reading. - Covers investigation techniques and interpretation of the results - Provides valuable information for how to deal with skeletal remains - Includes photos for most cases to clarify outcomes for the reader
The Mediastinal Mass
Tumors of the mediastinum are usually diagnosed in young patients, but they can develop at any age and form any tissue that exists in or passes through the chest cavity. The diagnosis and the accurate assessment of the mediastinum masses represents a challenge, given their clinical variability from asymptomatic to producing symptoms of cough, chest pain, and dyspnea. Mediastinal tumors encompass a wide range of various neoplasms. The localization of mediastinal masses is critical in the diagnosis: the anterior mediastinal masses are generally thymomas, teratomas, substernal thyroid/parathyroid tissue, or lymphomas; the middle mediastinum massess are typically pericardial and bronchogenic cys...
Identification of immune-related biomarkers for cancer diagnosis based on multi-omics data
description not available right now.
Practical Thoracoscopy
Diseases of the pleura such as effusion, thickening, or pneumothorax are frequently encountered in the practice of medicine. Practical Thoracoscopy presents an encyclopedic approach to the use of thoracoscopy in the diag nosis and treatment of patients with pleural disease. After an initial chapter on the history of thoracoscopy, the next three chapters of the book are devoted to the general technique of performing thoracoscopy, a topic on which the team of Dr. Boutin and his colleagues write with ample experience. In these chapters they provide detailed de scriptions of how to perform the procedure and discuss the pros and the cons of the different approaches and the different equipment ava...
