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This book is a printed edition of the Special Issue MicroRNA as Biomarkers in Cancer Diagnostics and Therapy that was published in IJMS
The treatment algorithm of locally advanced rectal cancer has been changing in the last years and a multidisciplinary approach is required to select effective and personalized treatment. Nowadays, total neoadjuvant treatment is an established validated strategy for high-risk rectal cancer patients as it showed and has shown increased complete response rate representing a new standard of care. Therefore, the selection of predictive molecular markers is, even more, an essential and pursued medical needs goal. Moreover, regarding the early stage of disease, one major question pertains to the risk of recurrence and minimal residual disease: when is staging based on pathologic features adequate for a shared therapeutic decision? This is one of the main issues concerning future advances.
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This book highlights the role and mechanism of different metal nanocomposites toward oxidative stress-induced metabolic disorders including metabolic pathways affected by oxidative stress and related pathophysiology. The book includes an illustrative discussion about the methods of synthesis, characterization, and biomedical applications of metal nanocomposites. It focuses on the therapeutic approaches for metabolic disorders due to oxidative stress by nano delivery systems. Moreover, the book includes chapters on nanotherapeutic approaches toward different diseases, including diabetes mellitus, obesity, cardiovascular disorders, cancers, and neurodegenerative diseases such as Alzheimer's di...
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