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Synthetic Biology-Guided Metabolic Engineering
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Individual Microbe: Single-Cell Analysis and Agent-Based Modelling
Recent technological advances in single-cell microbiology, using flow cytometry, microfluidics, x-ray fluorescence microprobes, and single-cell -omics, allow for the observation of individuals within populations. Simultaneously, individual-based models (or more generally agent-based models) allow for individual microbes to be simulated. Bridging these techniques forms the foundation of individual-based ecology of microbes (µIBE). µIBE has elucidated genetic and phenotypic heterogeneity that has important consequences for a number of human interests, including antibiotic or biocide resistance, the productivity and stability of industrial fermentations, the efficacy of food preservatives, an...
An Infectious Origin of Alzheimer’s Disease: An End for This Devastating Disorder?
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Grain & Noise - Artists in Synthetic Biology Labs
The collaboration between scientists and artists in the form of Artist-in-Lab residencies may not only cause a productive disturbance for a day's work in the laboratory, but also reveal new ways of understanding. Research and science communication company Biofaction has brought together artists and synthetic biologists throughout Europe in a residence program that spans four truly cross-disciplinary collaborations. The contributors to this volume share their reflections of the dynamic frictions that occurred when their artistic and scientific worlds met. These stories, where chemistry labs, tobacco plants, genetically edited bacteria, and new-to-nature enzymes collide with music, photography, film, and visual arts, infuse the ongoing dialogue between art and sciences with grain, noise, and synergies.
Engineering Corynebacterium Glutamicum Chassis for Synthetic Biology, Biomanufacturing, and Bioremediation
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Microbial Secondary Metabolites: Recent Developments and Technological Challenges
Research on microbes plays an essential role in the improvement of biotechnological and biomedical areas. It has turned into a subject of expanding significance as new organisms and their related biomolecules are being characterized for several applications in health and agriculture. Microbial biomolecules confer the ability of microbes to cope with a range of adverse conditions. However, these biomolecules have several advantages over the plant origin, which makes them a suitable target in drug discovery and development. The reasons could be that microbial sources can be genetically engineered to enhance the production of desired natural production by large-scale fermentation. The interacti...
Multi-Omics Technologies for Optimizing Synthetic Biomanufacturing
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2nd synthetic biology forum: system and synthetic biology for biofuels and bioproducts
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Actinobacteria, a Source of Biocatalytic Tools
Actinobacteria (Actinomycetes) represent one of the largest and most diverse phyla among Bacteria. The remarkable diversity is displayed by various lifestyles, distinct morphologies, a wide spectrum of physiological and metabolic activities, as well as genetics. Interestingly, most Actinobacteria have a high GC-content (ranging from 51% to >70%) and belong to Gram-positive or Gram-variable type microbes. Many species are well known for large genomes which may be of linear style as in case of rhodococci or circular. Many of those harbor linear megaplasmids as a kind of genetic storage device. Frequently gene redundancy is reported and in most cases the evolutionary history or a functional rol...
