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Multidrug Gram-Negative Bacilli : Current Situation and Future Perspective
Bacterial resistance has become a worldwide concern since patients with infections related to microorganisms have a higher risk to develop the worst outcomes, including death; in addition to greater consumption of hospital resources than those patients who become infected with susceptible microorganisms. Estimates have been made that, if this problem continues increasing, in 2050, there will be ten million deaths worldwide, more than those currently caused by cancer. Gram-negative bacilli, such as Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii are associated with higher rates of both community and hospital-acquired infections and unfortunately have been showing an alarming increase in the rates of resistance. In the last decade, the use of antibiotics has resurfaced, which in the past were discarded due to their toxicity associated, as therapeutic tools for many of these infections; meanwhile, new therapeutic options have emerged on the market that could be viable for the treatment of these bacterial infections depending on the resistance mechanisms involved.
The Global Threat of Carbapenem-Resistant Gram-Negative Bacteria
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Fundamentals of, and Applications Based on, Quorum Sensing and Quorum Sensing Interference
Background Bacteria use quorum sensing (QS) circuits to coordinate various activities (among which biofilm formation and the expression of virulence factors) based on the presence of signaling molecules. Different families of signal molecules have been identified in Gram positive and Gram negative bacteria (e.g. autoinducer peptides and acyl homoserine lactones). Similarly, different quorum sensing antagonists interfering with these system have been found in nature, promoting a new and promising field of research, quorum sensing interference. One of the most intensively studied applications of quorum sensing interference is its use as an alternative or synergycally with antibiotics to fight ...
Innovative Approaches in The Management of Bone and Joint Infection
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Application of Next Generation Sequencing (NGS) and CRISPR-Cas Systems in The Diagnosis of Infectious Diseases
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Bone and joint infection: past, present, and future
Bone and joint infections (BJI) cause serious morbidity and pose significant management challenges. They may cause acute sepsis with bone and joint destruction, discharging wounds, chronic pain, and permanent disability. With increasing age and expanding populations, bone and joint infections, especially those involving devices, will have a growing impact on healthcare resources. Specifically, one typical type of BJI, periprosthetic joint infection, is even more difficult to manage. Although the incidence of PJI is not high, the diagnosis is difficult; the treatment is complicated, and the efficacy is uncertain. Patients usually need to undergo multiple operations with long-term antibiotic treatment.
Guía de terapia antimicrobiana
Guía de terapia antimicrobiana recopila información microbiológica relevante para la toma de decisiones al pie de la cama del paciente, así como los aspectos fundamentales de los fármacos listados en tablas de fácil asimilación. Práctica. Diseño pragmático en forma de algoritmos para facilitar el abordaje terapéutico antimicrobiano en cualquier escenario clínico. Dinámica. Los algoritmos presentan la toma decisiones paso a paso basada en los resultados microbiológicos para ajustar el tratamiento de empírico a específico. Específica. Información microbiológica de distintos países de América Latina, así como datos locales para exponer un panorama de los patrones de resist...
Antimicrobial Resistance
Tackling the realities of the antimicrobial resistance (AMR) situation today is no longer uncommon. Many battles have been fought in the past since the discovery of antibiotics between man and microbes. In the tussle of new antibiotic modifications, the transmission of resistant genes, both vertically and horizontally unveils yet another resistant attribute for the microbe, for it only to be faced with a more powerful, wide spectrum antibiotic; the cycle continues-and the winner is yet to be known. This book aims to provide some insight into various molecular mechanisms, agricultural mitigation methods, and the One Health applications to maybe, just maybe, tip the scales towards us.
Quorum Network (Sensing/Quenching) in Multidrug-Resistant Pathogens
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
