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The Genetics of Complex Thyroid Diseases
The rapid developments in molecular genetics have clarified many of the muta tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis ease, and types I and II diabetes mellitus, the elucidation of susceptibility ge...
TSH Receptor and Autoimmunity
The present Research Topic aims to provide updated reviews on TSH receptor structure and function, and its relationship with thyroid autoimmunity. Indeed, original reviews deal also with the pathogenesis of Graves' disease and its complications such as thyroid-associated opthalmopathy. Another issue that is addressed in this topic is the multifaceted nature of TSH receptor autoantibodies (TRAbs) and their role in the diagnosis and prognosis of Graves’ disease, with the most recent data on the clinical applications of TRAbs assays. Furthermore, the functional role of the TSH receptor in extrathyroidal tissues is discussed.
Receptor Purification
The purpose of these volumes is to provide a reference work for the methods of purifying many of the receptors we know about. This be comes increasingly important as full-length receptors are overexpressed in bacteria or in insect cell systems. A major problem for abundantly expressed proteins will be their purification. In addition to purification protocols, many other details can be found concerning an individual receptor that may not be available in standard texts or monographs. No book of this type is available as a compendium of purification procedures. Receptor Purification provides protocols for the purification of a wide variety of receptors. These include receptors that bind: neurot...
Neuroblastoma
Introduction of new technologies and their applications to neuroblastoma diagnosis, treatment, and therapy assessment are explained. Role of molecular ghenetics in diagnosis and therapy for neuroblastoma patients is detailed. Molecular detection of minimal residual neuroblastoma is described. Magnetic resonance imaging and spectroscopy are detailed for diagnosing this solid, extracranial cancer. Targets for therapeutic intervention in neuroblastoma are identified, including targeting multidrug resistance in this cancer. Ornithine decarboxylase and polyamines are novel targets for therapeutic intervention. The effectiveness of chemotherapy with oral irinotecan and temozolomide is explained. The role of transcription factors (GATA) in neuroblastoma pregression is also included.
Glycoprotein Hormones
Advances in the field of glycoprotein hormones necessitated a second international symposium on this topic, held March 11 to 14, 1993, in Santa Barbara, California, and again sponsored by Serono Symposia, USA. The meeting was twofold in its concept: (1) the dissemination of the current research in the field and (2) honoring three scientists who have greatly contributed to this field, Drs. Harold Papkoff, Robert Ryan, and Darrell Ward, upon their retirements. We were honored to have Dr. John Pierre present as a participant at the meeting and also serving as master of ceremonies at the banquet. Certainly one of the highlights at the first meeting, held in 1989, was the cloning of the CG/LH rec...
Handbook of Behavior, Food and Nutrition
This book disseminates current information pertaining to the modulatory effects of foods and other food substances on behavior and neurological pathways and, importantly, vice versa. This ranges from the neuroendocrine control of eating to the effects of life-threatening disease on eating behavior. The importance of this contribution to the scientific literature lies in the fact that food and eating are an essential component of cultural heritage but the effects of perturbations in the food/cognitive axis can be profound. The complex interrelationship between neuropsychological processing, diet, and behavioral outcome is explored within the context of the most contemporary psychobiological research in the area. This comprehensive psychobiology- and pathology-themed text examines the broad spectrum of diet, behavioral, and neuropsychological interactions from normative function to occurrences of severe and enduring psychopathological processes.
Program 120 Male Handbook B
Program120 Male B Handbook on Preventive Medicine: A condensed version of the last half (on the benefit of hormones) of his famous Program 120 textbook on disease prevention, in this book Dr. Purser, a pituitary endocrinology researcher, lecturer and author, discusses normal lab values in men. He addresses proper testing, diagnoses, and hormone replacement therapy for hormones such as; somatropin, testosterone, thyroid, melatonin, and DHEA. Everything is highly referenced and researched. He also gives steps on how to make your levels normal and to make your life better!
Program 120 Female Handbook B
Program120 Female B Handbook on Preventive Medicine: A condensed version of the last half (on the benefit of hormones) of his famous Program 120 textbook on disease prevention, in this book Dr. Purser, a pituitary endocrinology researcher, lecturer and author, discusses normal lab values in women. He addresses proper testing, diagnosis, and hormone replacement therapy for hormones such as; somatropin, testosterone, thyroid, melatonin, progesterone, estradiol and DHEA. Everything is highly referenced and researched. He also gives steps on how to make your levels normal and to make your life better!
Williams Textbook of Endocrinology E-Book
Now fully revised and updated, Williams Textbook of Endocrinology, 15th Edition, remains your go-to reference for authoritative content on the full spectrum of adult and pediatric endocrine system disorders. World-renowned authors and editors expertly bridge the gap between basic science and clinical information, keeping you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field. - Presents current information in a highly illustrated, user-fri...
70 Years of Levothyroxine
This open access book presents the history, pharmacokinetics and pharmacodynamics of levothyroxine, discussing its role in the thyroid pathophysiology of patients of various ages and during pregnancy. It also describes the influence of levothyroxine on heart, bone and in cancer. When it was first synthesized in 1949, levothyroxine represented a significant advance in the treatment of hypothyroidism, providing a safe and effective treatment option for millions of hypothyroid patients around the globe. This synthetic form of thyroxine is now one of the most prescribed drugs in the world. Levothyroxine was first introduced by Merck KGaA,Darmstadt, Germany, in 1972, and since then the company has remained actively engaged in research on this mainstay of hypothyroidism treatment. This book is intended for healthcare professionals.
