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This volume provides recent advances in the field of biophysics of membrane proteins. Chapters are divided into several parts: detailing biochemistry and functional analysis, experimental and theoretical structural determinations, membrane protein dynamics, and conformation studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biophysics of Membrane Proteins: Methods and Protocols aims to provide comprehensive protocols with notes to help further the understanding of key membrane protein structure and function for students, academics, and industrial researchers.
Fundamentals of Renal Pathology is a compact and up-to-date resource on the basics of renal pathology that will be of particular value for residents and fellows in training in renal pathology, general pathology, and nephrology, but will also serve as a handy reference for the more experienced. This second, revised and updated edition of the book offers an integrated approach based on contributions from established experts in the field. Key diseases are discussed within the context of clinical presentations, with the emphasis on clinicopathological correlation and differential diagnosis. Topics discussed include glomerular diseases with nephrotic or nephritic syndrome presentations; systemic and vascular diseases affecting the kidney, including diseases affecting the renal transplant; tubulointerstitial diseases; and plasma cell dyscrasias and associated diseases. Well-chosen color illustrations and electron micrographs enhance and complement the text.
This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.
Following on from the successful book "Natural Born CAADesigners: Young American Architects", this book takes a look at the most recent architectonic developments in the Mediterranean countries, where architects have up to now been strongly influenced by the archaeologically significant environment and their classical architectural inheritance. How do young architects in Italy, France, Spain and Greece react to the new digital age? The electronic tools give them the chance to free themselves from the burden of tradition, to explore fascinating opportunities in their architecture. This book provides a colourful and concise overview of their work, using previously unpublished material. The team IAN+ was formed in 1997 in Rome by Carmelo Baglivo, Luca Galofaro and Stefania Manna. Maria Luisa Palumbo works at the McLuhan Programm in Culture and Technology.
Carlin, who is frightened by everything, wants to try some of Big Bear's bravery soup, but first he must travel through a dark forest to a monster's cave to retrieve an important ingredient.
Examining how the `here and now' of space, territory, the body, are being redefined by new technologies and how this undoes simplistic versions of the globalization thesis, Paul Virilio demonstrates how technology has made inertia the defining condition of modernity. An instantaneous present has replaced space and the sovereignty of territory; everything happens without the need to go anywhere. This book will be a key reference for students and scholars of the latest thinking in social theory.
How science changed the way artists understand reality Exploring the Invisible shows how modern art expresses the first secular, scientific worldview in human history. Now fully revised and expanded, this richly illustrated book describes two hundred years of scientific discoveries that inspired French Impressionist painters and Art Nouveau architects, as well as Surrealists in Europe, Latin America, and Japan. Lynn Gamwell describes how the microscope and telescope expanded the artist's vision into realms unseen by the naked eye. In the nineteenth century, a strange and exciting world came into focus, one of microorganisms in a drop of water and spiral nebulas in the night sky. The world is...
Heinz von Foerster was the inventor of second-order cybernetics, which recognizes the investigator as part of the system he is investigating. The Beginning of Heaven and Earth Has No Name provides an accessible, nonmathematical, and comprehensive overview of von Foerster’s cybernetic ideas and of the philosophy latent within them. It distills concepts scattered across the lifework of this scientific polymath and influential interdisciplinarian. At the same time, as a book-length interview, it does justice to von Foerster’s élan as a speaker and improviser, his skill as a raconteur. Developed from a week-long conversation between the editors and von Foerster near the end of his life, this work playfully engages von Foerster in developing the difference his notion of second-order cybernetics makes for topics ranging from emergence, life, order, and thermodynamics to observation, recursion, cognition, perception, memory, and communication. The book gives an English-speaking audience a new ease of access to the rich thought and generous spirit of this remarkable and protean thinker.