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This is a monograph on the concept of residual life, which is an alternative summary measure of time-to-event data, or survival data. The mean residual life has been used for many years under the name of life expectancy, so it is a natural concept for summarizing survival or reliability data. It is also more interpretable than the popular hazard function, especially for communications between patients and physicians regarding the efficacy of a new drug in the medical field. This book reviews existing statistical methods to infer the residual life distribution. The review and comparison includes existing inference methods for mean and median, or quantile, residual life analysis through medical data examples. The concept of the residual life is also extended to competing risks analysis. The targeted audience includes biostatisticians, graduate students, and PhD (bio)statisticians. Knowledge in survival analysis at an introductory graduate level is advisable prior to reading this book.
This book provides a groundbreaking introduction to the likelihood inference for correlated survival data via the hierarchical (or h-) likelihood in order to obtain the (marginal) likelihood and to address the computational difficulties in inferences and extensions. The approach presented in the book overcomes shortcomings in the traditional likelihood-based methods for clustered survival data such as intractable integration. The text includes technical materials such as derivations and proofs in each chapter, as well as recently developed software programs in R (“frailtyHL”), while the real-world data examples together with an R package, “frailtyHL” in CRAN, provide readers with useful hands-on tools. Reviewing new developments since the introduction of the h-likelihood to survival analysis (methods for interval estimation of the individual frailty and for variable selection of the fixed effects in the general class of frailty models) and guiding future directions, the book is of interest to researchers in medical and genetics fields, graduate students, and PhD (bio) statisticians.
In 2002, Lippincott published the Manual of Breast Diseases, edited by Professor Ismail Jatoi. The current book, Management of Breast Diseases, is an adaptation of that manual, with Professor Manfred Kaufmann of the Goethe-University of Frankfurt serving as co-editor. Most of the chapters from the original manual have been either extensively revised or discarded, and several new chapters added. This text contains more material than the original manual, but it is still intended as a basic guide for the wide spectrum of clinicians (surgeons, gynecologists, oncologists, radiation onco- gists, internists, general practitioners) who treat breast diseases, both benign and malignant. To compile thi...
The FRCS examination is the last hurdle on the road to independent practice as a consultant surgeon in the United Kingdom and Ireland. The voce viva portion of the exam can be particularly challenging for candidates who must demonstrate not only their knowledge of various surgical topics, but also their reasoning and decision-making abilities.Crack
"Although physicians make use of science, this book argues that medicine is not itself a science, but rather an interpretive practice that relies heavily on clinical reasoning." "In How Doctors Think, Kathryn Montgomery contends that assuming medicine is strictly a science can have adverse effects. She suggests these can be significantly reduced by recognizing the vital role of clinical judgment."--BOOK JACKET.
The emergence of high-speed computing has facilitated the development of many exciting statistical and mathematical methods in the last 25 years, broadening the landscape of available tools in statistical investigations of complex data. Biostatistics: A Computing Approach focuses on visualization and computational approaches associated with both modern and classical techniques. Furthermore, it promotes computing as a tool for performing both analyses and simulations that can facilitate such understanding. As a practical matter, programs in R and SAS are presented throughout the text. In addition to these programs, appendices describing the basic use of SAS and R are provided. Teaching by exa...
Smart metrics, slow thinking, off-label drugs, and a “Moneyball” prescription for fixing modern medicine--by the author of Tripping Over the Truth The United States is fast becoming the sickest nation in the Western world. Cancer rates continue to rise. There is an epidemic of chronic disease in children. Even with all the money and modern innovations in science, the country’s health care system is beyond broken. Clearly there is a glitch in the system. But what if the solution has been here all along, and we’ve just been too blind to see it? In Curable journalist and health care advocate Travis Christofferson looks at medicine through a magnifying glass and asks an important questio...
This book is a compilation of research accomplishments in the fields of modeling, simulation, and their applications, as presented at AsiaSim 2011 (Asia Simulation Conference 2011). The conference, held in Seoul, Korea, November 16–18, was organized by ASIASIM (Federation of Asian Simulation Societies), KSS (Korea Society for Simulation), CASS (Chinese Association for System Simulation), and JSST (Japan Society for Simulation Technology). AsiaSim 2011 provided a forum for scientists, academicians, and professionals from the Asia-Pacific region and other parts of the world to share their latest exciting research findings in modeling and simulation methodologies, techniques, and their tools and applications in military, communication network, industry, and general engineering problems.
Under the motto “Healthcare Technology for Developing Countries” this book publishes many topics which are crucial for the health care systems in upcoming countries. The topics include Cyber Medical Systems Medical Instrumentation Nanomedicine and Drug Delivery Systems Public Health Entrepreneurship This proceedings volume offers the scientific results of the 6th International Conference on the Development of Biomedical Engineering in Vietnam, held in June 2016 at Ho Chi Minh City.