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Emerging Functions of Septins
Together with the microfilament, microtubule and intermediate-filament networks, septins constitute an integral part of the eukaryotic cytoskeleton. Historically identified as proteins critical for septum formation in the budding yeast Saccharomyces cerevisiae, septin family GTPases are expressed and participate in the process of cytokinesis in most eukaryotes except higher plants. More than a dozen septin genes in mammals, together with various splice variants displaying tissue-specific expression patterns and flexible hetero-polymeric higher-order assembly achieve an unfathomable complexity superior to the other cytoskeletal components. Even though the initial studies in the septin field w...
Cytokine-Ion Channel Interactions in Pulmonary Inflammation
This Research Topic assembles original contributions and reviews from an international consortium of PIs related to interactions between pro-inflammatory cytokines and ion channels during acute lung injury and chronic heart failure.
Mechanisms and Consequences of Proton Transport
This volume represents the proceedings of the 9th International Proton Transport Conference, "Mechanisms and Consequences of Proton Transport" held in Leura, Australia, August 19 -21, 200 I. This conference has been held since 1971 every 3 to 4 years with few exceptions in association with the Congress of the International Union of Physiological Sciences. The first meeting was held in Frankfurt, Germany, at the Max-Planck'Institute. Countries hosting the conference have been Germany (twice), Sweden (twice), India, Canada, USA, Great Britain, and now Australia. Over the past 30 years participants at these Proton Transport Conferences have been principal contributors to the major discoveries in the physiology, biochemistry and pharmacology of gastric acid secretion. These include development of the H2-receptor blockers, defining the signaling pathways for the regulation of acid secretion, identifying the gastric proton pump, discovery and development of proton pump inhibitory drugs, and elucidating the physiology and biochemistry of Helicobacter pylori.
Encyclopedia of Gastroenterology
This comprehensive three-volume encyclopaedia contains over 450 articles describing all significant aspects of the discipline of gastroenterology. It covers topics such as: heartburn; ulcers; gallstones; colorectal cancer; hepatitis, and irritable bowel syndrome.
Acid Related Diseases
This textbook explores the history, biology, and treatment of acid related diseases, including gastric and duodenal ulcer disease, gastroesophageal reflux disease (GERD), and the role of H. pylori. The text offers thorough coverage of the subject matter, with an in-depth historical and biological focus. Equal focus is given to the biology and pharmacology of acid secretion and to the specific disease states of ulcers and GERD. This edition is full of new full-color medical illustrations of all aspects of this topic.
Na, K-ATPase and Related Cation Pumps
This text focuses on research on the structure, molecular mechanisms, physiological regulation, and involvement in disease of Na, K-ATPase and other members of the family of cation pumps. Prominent members of this family include gastric H, K-ATPase, Ca-ATPase of sarcoplasmic and endoplasmic reticulum, plasma membrane Ca-ATPase, and plasma membrane of H-ATPase of fungi and higher plants, as well as heavy metal pumps. The volume includes details of the first high-resolution structure ever obtained of a P-type pump, the sarcoplasmic reticulum Ca-ATPase; this structure has great predictive power relative to all P-type pumps. There are 50 papers and 97 poster papers altogethe
The Regulation of Urease Activity in the Gastric Pathogen Helicobacter Pylori
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Handbook of ATPases
ATP-dependent active ion transport enables cells to regulate their pH value and to control their ion composition. The reverse process, transforming an ion imbalance into chemical energy, drives mitochondrial and chloroplast ATP synthesis. The mediators of these fundamental processes are ion-motive ATPases, highly conserved enzymes that play key roles in cell physiology from bacteria to man. As the first comprehensive overview of this important class of enzymes, this handbook summarizes recent knowledge about the molecular mechanism of ATPases, relating this information to the physiology and pathopyhsiology of ion transport, mitochondrial function, vesicle transport and lysosomal acidification. All important P-type, F-type and V-type ATPases are treated systematically, complemented by a special section on the cell biology and physiology of acidic compartments, and backed by an extensive bibliography and index. This premier reference source for physiologists, molecular biologists, biophysicists and clinical researchers contains contributions by the world's foremost ATPase research groups.
